ea0089c19 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2022
Cordero-Hernandez Igryl S.
, Ross Alicia C.
, Dasari Arvind
, Halperin Daniel M.
, Chasen Beth
, Yao James C.
Background: We observed patients with well-differentiated NETs who received PRRT with 177Lu-dotatate and later developed rapid disease progression with biopsy-proven histologic transformation to NECs, an outcome that has not been previously described. In this series, we characterize the clinicopathologic features and outcomes of patients whose tumors underwent poorly-differentiated transformation.Methods: After obtaining IRB approval, we condu...